Skip to content

While there have been great advances in combating blood-borne viruses such as HIV and viral hepatitis, other diseases are increasing worldwide. Diseases of this type affect people of all ages, genders and socio-economic groups.

The more we understand how these diseases work, the more we can protect the health of our communities. We study every aspect of infectious disease, from biology and pathology to epidemiological studies, economic and population health.

We are building our capacity to develop evidence-based interventions. To translate research into clinical practice and policy. And to share knowledge that improves the care patients receive.


We are developing a truly integrated culture, to encourage collaboration between partners. We are supporting researchers to move beyond their own disciplines. To explore new ways to conduct research in interdisciplinary teams. It’s our aim to add value across the local and global research landscape.

We will do this by focusing on the following:

  • Prevention and treatment of infectious disease
  • Immunity with a focus on immune dysregulation
  • Inflammation and the consequences of inflammation-associated disease

We are creating working groups to conduct activity and bring researchers together across key focus areas, including allergy, antimicrobials, autoimmunity, inflammatory bowel disease, liver disease and cancer, as well as primary immunodeficiency.


Our researchers have a history of producing robust data, which can be generalised for a broader population. They are adept at taking this data and quickly turning it into clinical and policy improvements that directly benefit patients. We create multidisciplinary teams to take this expertise further progress our research faster. 


Covering a geographic area that spans East and West Sydney, from the Garvan Institute and St Vincent’s Hospital to Prince of Wales and St George, to Liverpool, Campbelltown and The Children's Hospital at Westmead, we also have members from UNSW Sydney, University of Technology Sydney and Western Sydney University. We partner with The George Institute, St Vincent’s Centre for Applied Medical Research and the Centre for Big Data Research in Health.

Our Lead staff are:

Professor Anthony Kelleher
Professor Liz Harry
A/Professor Gail Matthews
Professor Nicholas Shackel
Professor William Rawlinson
Professor Christopher Goodnow

Many of our researchers are also clinicians who work in:

South Eastern Sydney Local Health District
South Western Sydney Local Health District
St Vincent's Hospital, Sydney
Sydney Children’s Hospital, Randwick

We will draw on the strength of this existing research to grow infection, inflammation and immunity research into the future. We will integrate our expertise and resources across these regions to deliver world-class research.


A world where human health is enriched by controlling infection, enhancing immunity and managing inflammation.


We are building networks to enhance impact in areas of great need. These networks include:

-The SOMAD (somatic mutations in autoimmune disease) network is extending the search for rogue B cell clones and the self-reactive antibodies they produce in patients with autoimmune disease to understand how their cells differ from those of healthy people.

The Sydney Paediatric and Allergy Network (SPAAN) are de-labelling patients with previous antibiotic allergies in adult and kids allergy services to promote the rational use of antibiotics and standardise clinical care in an area prone to variation.

Improve global health:

For more information on our work, contact Dr Sam McAllery, Executive Officer.

A national effort to strengthen consumer and community involvement

SPHERE is co-leading a national collaborative effort with AHRA members to accelerate the implementation of best practice Consumer and Community Involvement (CCI) in Australia.

Learning, sharing and weaving

Understanding Aboriginal perspectives and cultural knowledge was the subject of this outstanding Applied Indigenous Research Methods workshop.

2023 Seed Funding Grant recipients announced

We are excited to announce the recipients of the 2023 SPHERE Seed Funding Grants.